期刊
CHROMOSOME RESEARCH
卷 15, 期 5, 页码 667-679出版社
SPRINGER
DOI: 10.1007/s10577-007-1149-7
关键词
homologous recombination; meiosis; telomerase; telomeres; t-loop
资金
- Cancer Research UK [A6444] Funding Source: Medline
Telomeres are essential for genomic stability and their dysfunction has been implicated in cancer and ageing. The most prominent function of the telomeres is to protect chromosome ends against degradation and fusion, which, in turn, requires maintenance of telomere DNA to a critical length that allows assembly of end-capping structures. During early meiosis, telomeres play the distinctive function of anchoring chromosomes to the inner nuclear membrane. Subsequently, as a consequence of the nuclear membrane polarization, telomeres cluster together into a bouquet configuration, which facilitates pairing and recombination of the homologous chromosomes. Here we review how the two fundamental aspects of telomere maintenance, elongation and protection, contribute to the essential functions performed by telomeres during meiosis.
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