期刊
CHEMISTRY-A EUROPEAN JOURNAL
卷 13, 期 7, 页码 2012-2022出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.200600735
关键词
alkynes; homogeneous catalysis; hydroamination; isoquinoline; titanium
Amidate-supported titanium amido complexes are efficient and regioselective precatalysts for intermolecular hydroamination of terminal alkynes with primary amines. The synthesis and characterization of the first bis(amidate)-supported titanium-imido complex is reported. Its role as the active catalytic species is suggested in the course of product distribution studies using deuterated substrates. The bis (amidate)-supported precatalysts exhibit good functional-group tolerance, even performing hydroaminations in the presence of ester and amide groups. This functional-group tolerance was exploited in the synthesis of a variety of 1-substituted tetrahydroisoquinoline alkaloids and a one-pot hydroaminative procedure for the high yielding preparation of the benzo[a]quinolizine skeleton.
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