期刊
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
卷 2007, 期 8, 页码 1301-1308出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200600833
关键词
biaryls; calpain inhibitors; macrocycles; peptide-biphenyl hybrids; solid-phase synthesis
The synthesis of a 24-membered macrocyclic peptide-biphenyl hybrid with four amino acid residues and two biphenyl fragments was performed by a combination of solid-phase and solution methodologies. The acyclic precursor was prepared by a solid phase methodology whereas the final macrocyclization was carried out by diisopropylcarbodiimide (DIPCDI) and N-hydroxybenzotriazole (HOBt) in solution. The target molecule was a moderate inhibitor of p-calpain. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007).
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