期刊
MEDICAL HYPOTHESES
卷 69, 期 5, 页码 1074-1075出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.mehy.2006.08.048
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Papers from a generation ago suggested that phenothiazines - in particular trifluorperazine (Stelazine) a medicinal approved by the FDA and still commonly used for schizophrenia - downregulate the epidermal growth factor receptor. As numerous cancers - e.g., colon cancer, breast cancer, pancreatic cancer and glioblastoma - are dependent on signaling via this receptor, we here suggest that phenothiazines such as trifluorperazine be considered for use in epidermal growth factor receptor associated cancers. (c) 2007 Elsevier Ltd. All rights reserved.
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