期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 5, 期 14, 页码 2291-2301出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b706331h
关键词
-
The efficient synthesis of fluorescent and non-fluorescent multivalent neoglycoconjugates is described by means of the Cu(I) catalyzed azide-alkyne 1,3-dipolar cycloaddition (click-chemistry). A well-defined glycopolymer, glycocyclodextrin or glycocluster architecture displaying galactose or lactose epitopes has been chosen. Cellular assays using U-937 and RAW 264.7 monocyte/macrophage cells showed that these glycocompounds have the capability to act as synthetic activators mimicking the lipopolysaccharide (LPS) effects. Thus, the click compounds promote cell adhesion and stimulation of monocytes, measured as an increase in the amount of TNF alpha, facilitating their differentiation to macrophages.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据