期刊
BIOPOLYMERS
卷 88, 期 2, 页码 300-307出版社
WILEY
DOI: 10.1002/bip.20670
关键词
kojic acid peptide derivatives; tyrosinase inhibitor; whitening agent; stability
Twenty two kojic acid-tripeptide amides were prepared using a solid-phase Fmoc/tBu strategy with Rink Amide SURk (R) resin. To effectively obtain kojic acid-tripeptide amide conjugates, the coupling conditions of kojic acid to the tripeptide on the resin were optimized. The tyrosinase inhibitory activity of kojic acid-tripeptide amides and the effect of the amino acid sequence on the activity were compared with those of kojic acid-tripeptide acids. The stability of kojic acid-tripeptide amides were then compared with those of kcjic acid and kojic acid-tripeptides acids. As a consequence, kojic acid-FWY-NH2 proved to be the best compound, with the highest inhibitory activity, which was maintained over different storage times tinder various temperatures and pHs. (c) 2007 Wiley Periodicals, Inc.
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