期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 73, 期 5, 页码 1054-1058出版社
SPRINGER
DOI: 10.1007/s00253-006-0577-1
关键词
lovastatin; Monascus purpureus; optimization; response surface methodology
Lovastatin, an inhibitor of HMG-CoA reductase, was produced by submerged fermentation using Monascus purpureus MTCC 369. Five nutritional parameters screened using Plackett-Burman experimental design were optimized by Box-Behnken factorial design of response surface methodology for lovastatin production in shake flask cultures. Maximum lovastatin production of 351 mg/l were predicted in medium containing 29.59 g/l dextrose, 3.86 g/l NH4Cl, 1.73 g/l KH2PO4, 0.86 g/l MgSO4 center dot 7H(2)O, and 0.19 g/l MnSO4 center dot H2O using response surface plots and point prediction tool of DESIGN EXPERT 7.0 (Statease, USA) software.
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