期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 5, 期 6, 页码 945-951出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/b617256c
关键词
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A one-pot, effective synthesis of pyridines by a modified Krohnke procedure is described. Polysubstituted annulated pyridines were synthesized in high yields by four-component, one-pot cyclocondensation reactions of N-phenacylpyridinium bromide, aromatic aldehydes, acetophenones or cyclic ketones in the presence of ammonium acetate and acetic acid, assisted by microwave irradiation. In this procedure, cyclic ketones with two alpha-CH2 groups yield annulated pyridines with additional alpha-benzylidene groups, which are derived in situ from double aldol condensation of cyclic ketones with two moles of aromatic aldehydes.
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