期刊
BIOLOGICAL & PHARMACEUTICAL BULLETIN
卷 30, 期 9, 页码 1624-1627出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.30.1624
关键词
phosphoinositide; tumor suppressor; phosphatase
The tumor suppressor phosphatase and tensin homolog (PTEN) functions as a phosphoinositide 3-phosphatase, that antagonizes phosphatidylinositol 3-kinase action, and negatively regulates cell proliferation and survival signals. Inactivation of PTEN by loss-of-function mutations gives rise to deregulated hyperproliferation of cells, leading to oncogenic transformation. Recent studies have identified a number of upstream regulatory factors for PTEN and unveiled that the impairment in the PTEN regulatory system potentially becomes a causal factor for oncogenic transformation of cells. This article will review the PTEN inactivation mechanism which is linked to human tumorigenesis, particularly focusing on recent research progress in PTEN regulators.
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