期刊
EUROPEAN JOURNAL OF CANCER
卷 43, 期 6, 页码 979-992出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2007.01.004
关键词
hepatocellular carcinoma; molecular markers; prognosis
类别
资金
- MRC [G0100872] Funding Source: UKRI
- Medical Research Council [G0100872] Funding Source: Medline
Hepatocellular carcinoma (HCC) is the fifth commonest malignancy worldwide and its incidence is rising. Surgery, including transplantation, remains the only potentially curative modality for HCC, yet recurrence rates are high and long-term survival poor. The ability to predict individual recurrence risk and subsequently prognosis would help guide surgical and chemotherapeutic treatment. As understanding of hepatocarcinogenesis has increased, the myriad of genetic and molecular events that drive the hepatocarcinogenic disease process, including angiogenesis, invasion and metastasis, have been identified. This systematic review examines the evidence from published manuscripts reporting the prognostic potential of molecular biomarkers in hepatocellular carcinoma. In summary, a number of molecular biomarkers with prognostic significance have been identified in hepatocellular carcinoma. Not only might these molecules allow more accurate prediction of prognosis for patients with HCC, but they may also provide targets for potential therapeutic agents. (C) 2007 Elsevier Ltd. All rights reserved.
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