期刊
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
卷 80A, 期 3, 页码 635-643出版社
WILEY-LISS
DOI: 10.1002/jbm.a.30969
关键词
laser processing; direct writing; tissue engineering; zirconia; hydroxyapatite
We have developed a novel approach for layer-by-layer growth of tissue-engineered materials using a direct writing process known as matrix assisted pulsed laser evaporation direct write (MAPLE DW). Unlike conventional cell-seeding methods, this technique provides the possibility for cell-material integration prior to artificial tissue fabrication. This process also provides greater flexibility in selection and processing of scaffold materials. In addition, MAPLE DW offers rapid computer-controlled deposition of mesoscopic voxels at high spatial resolutions. We have examined MAPLE DW processing of zirconia and hydroxyapatite scaffold materials that can provide a medical device with nearly inert and bioactive implant-tissue interfaces, respectively. We have also demonstrated codeposition of hydroxyapatite, MG 63 osteoblast-like cells, and extracellular matrix using MAPLE DW. We have shown that osteoblast-like cells remain viable and retain the capacity for proliferation when codeposited with bio-ceramic scaffold materials. Our results on MG 63-hydroxy-apatite composites can be extended to develop other integrated cell-scaffold structures for medical and dental applications. (c) 2006 Wiley Periodicals, Inc.
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