Synthesis and biological evaluation of new 4-deacety-1,7,9-trideoxy-10-oxopaclitaxeI via sinenxan A

A new 4-deacety-1,7,9-trideoxy-10-oxopaclitaxel (compound 1) was prepared in 21 steps via sinenxan A, a biosynthetic taxane. The biological evaluation in vitro against human cancer lines showed compound 1 to be devoid of cytotoxicity.