Microwave-promoted, solvent-free, three-component coupling of aldehyde, alkyne, and amine catalyzed by AgNO3

An efficient three-component coupling reaction of alkyne, aldehyde, and amine was carried out in one pot smoothly under the catalysis of AgNO3 and microwave irradiation. The scope of reaction substrates was extended. Moreover, the reaction can be performed under solvent-free condition, affording propargylarnine derivatives with high yields.