Iodine-catalyzed, one-pot, solid-phase synthesis of benzothiazole derivatives

Molecular iodine was utilized in a one-pot, solid-phase, solvent-free reaction between 2-aminothiophenol and benzoic acid derivatives to obtain highly economical and excellent yield of benzothiazole derivatives in comparison to polyphosphoric acid- and [pmlm]-Br-catalyzed microwave synthesis reactions. The results of the studies revealed that the new method reduces cost by approximately 17-fold in comparison to polyphosphoric acid and has a significant cost reduction in comparison to pmIm]-Br. Moreover, it becomes even more economical because no additional chemicals and solvents are necessary for the reaction.