期刊
THROMBOSIS RESEARCH
卷 121, 期 1, 页码 67-73出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.thromres.2007.02.010
关键词
disseminated; intravascular coagulation (DIC); D-dimer; fibrinolysis; neutrophil elastase; sepsis; urinary trypsin inhibitor (UTI)
Introduction: We conducted a prospective study to test the hypothesis that the activation of neutrophil elastase-mediated fibrinolysis is insufficient to overcome the fibrinolytic shutdown of disseminated intravascular coagulation (DIC) in patients associated with systemic inflammation. Materials and methods: We investigated 45 consecutive patients with systemic inflammatory response syndrome (SIRS) and sepsis, classified as 11 DIC and 34 non-DIC. Fibrin degradation products by neutrophil elastase (Elastase-XDP) and by plasmin (FDP), cross-linked fibrin degradation products (D-dimer), soluble fibrin, antithrombin, protein C, plasminogen activator inhibitor-1 (PAI-1), and urinary trypsin inhibitor (UTI) were measured within 24 In after the patients met either the SIRS or sepsis criteria (day 0), as well as on days 2 and 4. Results: In DIC patients, higher levels of soluble fibrin, PAI-1, and FDP and markedly lower levels of antithrombin and protein C were observed in comparison to those in non-DIC patients. DIC patients showed a significantly higher level of peak Elastase-XDP than non-DIC patients (25.7 +/- 5.9 vs. 16.3 +/- 2.6 mu g/mL, respectively; p=0.0333). However, we could not find any substantial difference in the levels of Elastase-XDP,
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