期刊
HORMONE RESEARCH
卷 68, 期 -, 页码 166-172出版社
KARGER
DOI: 10.1159/000110617
关键词
acromegaly; growth hormone; insulin-like growth factor-I; mortality
Background: Increased production of growth hormone (GH) and insulin-like growth factor-I (IGIF-I) in patients with acromegaly is associated with a twofold increase in mortality compared with the general population. The range of standardised mortality rates in various studies ranges from 1.2 to 3.6. Predictors of Mortality: Multivariate analysis has indicated that post-treatment serum GH levels and, in a number of studies, serum IGF-I levels are the most powerful predictors of outcome. Normal IGF-I concentrations and random GH levels <2.5 mu g/l measured by polyclonal radioimmunoassay result in optimal outcome. Other factors adversely influencing mortality include hypertension and a long interval between onset of the disorder and diagnosis. Conclusions: Analysis of recent reports suggests that adoption of treatment guidelines with appropriate post-treatment target ranges for GH and IGF-I, together with the availability of newer methods to control GH oversecretion, has significantly improved patient outcomes. Copyright (C) 2007 S. Karger AG, Basel.
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