期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 71, 期 1, 页码 226-230出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.60314
关键词
Allium tuberosum Rottl.; choline acetyltransferase (ChAT); ferulic acid [4-hydroxy-3-methoxycinnamic acid]; Alzheimer's disease; acetylcholine (Ach)
An ethanolic extract of Allium tuberosum Rottl. demonstrated potent choline acetytrasferase (ChAT) activating activity (45%) among 30 screened Korean edible plants. The ChAT activator of A. tuberoum Rottl. was purified and identified as ferulic acid [4-hydroxy-3-methoxycinnamic acid] via silica-gel open-column chromatography, HPLC, EI-MS, and H-1/C-13-NMR. The ferulic acid from A. tuberoum Rottl. exhibited ChAT activity in a dose-dependent manner and showed notoxicity in a cell viability assay (MTT assay). We suggest that the ferulic acid from A. tuberoum Rottl. was the strong ChAT activator.
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