期刊
JOURNAL OF PROTEOME RESEARCH
卷 6, 期 7, 页码 2565-2575出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr070012k
关键词
EAE; multiple sclerosis; iTRAQ; mass spectrometry; spinal cord
资金
- NINDS NIH HHS [P30 NS046593, R01 NS046363, NS046363, NS046593, P30 NS046593-04, R01 NS046363-04, F31 NS054336] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P30NS046593, F31NS054336, R01NS046363] Funding Source: NIH RePORTER
The present study used isobaric tags for relative and absolute quantitation (iTRAQ) to identify novel targets in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. The expression of 41 proteins was significantly altered in the inflamed spinal cord. Twenty of these are implicated in EAE for the first time and many have previously been shown to play a role in antigen processing, inflammation, neuroprotection, or neurodegeneration.
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