期刊
LEUKEMIA & LYMPHOMA
卷 48, 期 3, 页码 497-505出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/10428190601175393
关键词
chronic phase CML; pegylated interferon; treatment-naive; interferon
The efficacy and safety of peginterferon-alpha-2 alpha (40 kD) (PEG-IFN alpha-2a), 450 mu g once weekly, versus IFN alpha-2a, 9 MIU once daily, for 12 months, was evaluated in a Phase II study in IFN-naive patients with chronic-phase, Philadelphia-chromosome-positive CML. At the end of the treatment, complete hematological response was observed in 66.2% (47/71) and 45.2% (33/73) of the PEG-IFN alpha-2a group and IFN alpha-2a groups, respectively (p = 0.009), and major cytogenetic response occurred in 35.2% and 17.8%, respectively (p = 0.016). PEG-IFN alpha-2a was at least as effective as IFN alpha-2a overall, including progression-free survival at the end of treatment, and overall survival after 30 months of follow-up. Adverse events necessitated fewer withdrawals but more dose adjustments in the PEG-IFN alpha-2a group compared with the IFN alpha-2a group (11% versus 23%, and 84.5% versus 65.8%, respectively). In conclusion, PEG-IFN alpha-2a (40 kD), 450 mg once weekly, compared with IFN alpha-2a, 9 MIU once daily, resulted in higher rates of hematologic and cytogenetic response and greater overall survival.
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