期刊
JOURNAL OF BIOMECHANICS
卷 40, 期 2, 页码 390-398出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jbiomech.2005.12.011
关键词
collagen fibril; proteoglycan; fibril-to-fibril interaction; mitral valve chordae tendineae
资金
- NHLBI NIH HHS [R01 HL057236] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL057236] Funding Source: NIH RePORTER
In highly aligned connective tissues, such as tendon, collagen fibrils are linked together by proteoglycans (PGs). Recent mechanical and theoretical studies on tendon micromechanics have implied that PGs mediate mechanical interactions between adjacent collagen fibrils. We used transmission electron microscopy to observe the collagen fibril-PG interactions in porcine mitral valve chordae under variable loading conditions and found that PGs attached to collagen fibrils perpendicularly in the load-free situation, and became skewed when the chordae were loaded. The average skewness angle of PGs increased with the applied load, and hence the strain in the chordae. The observation of PG skewing with the application of load demonstrates that, in mitral valve chordae, interfibrillar slippage occurs and that PGs play a role in fibril-to-fibril interaction and likely transfer force. The results of this study provide new insights into the mechanical role of PGs and support some recent theoretical models. (c) 2006 Elsevier Ltd. All rights reserved.
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