期刊
ADVANCES IN SPACE RESEARCH
卷 40, 期 4, 页码 506-512出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.asr.2007.05.070
关键词
microarrays; gene expression patterns; microgravity; International Space Station; Drosophila melanogaster; Caenorhabditis elegans; European Soyuz missions; Spanish Cervantes mission; Dutch Delta mission
类别
资金
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR054342] Funding Source: NIH RePORTER
- NIAMS NIH HHS [R01 AR054342-01A1] Funding Source: Medline
The European Soyuz missions have been one of the main routes for conducting scientific experiments onboard the International Space Station, which is currently in the construction phase. A relatively large number of life and physical sciences experiments as well as technology demonstrations have been carried out during these missions. Included among these experiments are the Gene experiment during the Spanish Cervantes Soyuz mission and the ICE-1st experiment during the Dutch Delta mission. In both experiments, full genome microarray analyses were carried out on RNA extracted from whole animals recovered from the flight. These experiments indicated relatively large scale changes in gene expression levels in response to spaceflight for two popular model systems, Drosophila melanogaster (Gene) and Caenorabditis elegans (ICE-1st). Here we report a comparative analysis of results from these two experiments. Finding orthologous genes between the fruit fly and the nematode was far from straightforward, reducing the number of genes that we could compare to roughly 20% of the full comparative genome. Within this sub-set of the data (2286 genes), only six genes were found to display identical changes between species (decreased) while 1809 genes displayed no change in either species. Future experiments using ground simulation techniques will allow producing a better, more comprehensive picture of the putative set of genes affected in multicellular organisms by changes in gravity and getting a deeper understanding of how animals respond and adapt to spaceflight. (c) 2007 COSPAR. Published by Elsevier Ltd. All rights reserved.
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