期刊
INTERNAL MEDICINE
卷 46, 期 12, 页码 873-877出版社
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.46.6395
关键词
diabetes; cytomegalovirus; ketoacidosis; GAD65
We report the case of a 59-year-old woman who developed rapid-onset type 1 diabetes associated with a marked increase in anti-glutamic acid decarboxylase antibody titer (317.5 U/ml), mild increase in HbA1c level (6.8%), diabetic ketoacidosis, and cytomegalovirus enterocolitis. She was a heterozygote for HLA class II DRB1* 0901-DQA1* 03-DQB1* 0303, and she had HLA class I A24, which may have contributed to the rapid beta cell destruction. Based on the putative molecular mimicry of GAD65 by cytomegalovirus antigen, we hypothesize that the type 1 diabetes in this case was associated with cytomegalovirus infection.
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