期刊
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
卷 71, 期 1, 页码 242-245出版社
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.60441
关键词
ATP-binding cassette (ABC) transporter; berberine; multidrug resistance protein (MDR); multidrug resistance associated protein (MRP); transport
To examine whether human ATP-binding cassette (ABC) transporters play a role in the detoxification of plant alkaloid berberine, we investigated berberine transport using multidrug resistance protein1 (MDRI) and multidrug resistance-associated proteinl (MRP1). Cells expressing MDR1 or MRP1 accumulated less berberine. Berberine accumulation depended on the cellular ATP level, and was reversed by typical inhibitors of MDR1, suggesting that human MDR1 and MRP1 directly efflux berberine as their substrate.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据