期刊
JOURNAL OF PROTEOME RESEARCH
卷 6, 期 5, 页码 1899-1916出版社
AMER CHEMICAL SOC
DOI: 10.1021/pr060393m
关键词
intrinsic disorder; protein structure; protein function; intrinsically disordered proteins; bioinformatics; disorder prediction
资金
- NIGMS NIH HHS [R01 GM071714-01A2, R01 GM071714] Funding Source: Medline
- NLM NIH HHS [LM007688-0A1, R56 LM007688, R01 LM007688, R01 LM007688-01A1] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM071714] Funding Source: NIH RePORTER
- NATIONAL LIBRARY OF MEDICINE [R56LM007688, R01LM007688] Funding Source: NIH RePORTER
Biologically active proteins without stable ordered structure (i.e., intrinsically disordered proteins) are attracting increased attention. Functional repertoires of ordered and disordered proteins are very different, and the ability to differentiate whether a given function is associated with intrinsic disorder or with a well-folded protein is crucial for modern protein science. However, there is a large gap between the number of proteins experimentally confirmed to be disordered and their actual number in nature. As a result, studies of functional properties of confirmed disordered proteins, while helpful in revealing the functional diversity of protein disorder, provide only a limited view. To overcome this problem, a bioinformatics approach for comprehensive study of functional roles of protein disorder was proposed in the first paper of this series (Xie, H.; Vucetic, S.; Iakoucheva, L. M.; Oldfield, C. J.; Dunker, A. K.; Obradovic, Z.; Uversky, V. N. Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J. Proteome Res. 2007, 5, 1882-1898). Applying this novel approach to Swiss-Prot sequences and functional keywords, we found over 238 and 302 keywords to be strongly positively or negatively correlated, respectively, with long intrinsically disordered regions. This paper describes similar to 90 Swiss-Prot keywords attributed to the cellular components, domains, technical terms, developmental processes, and coding sequence diversities possessing strong positive and negative correlation with long disordered regions. Keywords: intrinsic disorder center dot protein structure center dot protein function center dot intrinsically disordered proteins center dot bioinformatics center dot disorder prediction
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