期刊
INTERNAL MEDICINE
卷 46, 期 2, 页码 77-79出版社
JAPAN SOC INTERNAL MEDICINE
DOI: 10.2169/internalmedicine.46.1775
关键词
Smoking; protease-antiprotease imbalance; oxidant-antioxidant imbalance; Gene-Association Studies; adenoviral latent infection may
资金
- Mitsui Life Social Welfare Foundation
Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow limitation in the lungs. Smoking is one of the amongst major risk factors for the development of COPD. Environmental pollution, age, and airway hyperreactivity are also the risk factors. The protease-antiprotease imbalance and the oxidant-antioxidant imbalance cause airway inflammation and destruction. The genes related to these balances may contribute to development of COPD pathology. Candidate gene-association studies and linkage analyses have been reported for COPD patients. The alpha-1 antitrypsin, glutathione S-transferase, microsomal epoxide hydrolase, and matrix metalloproteinase, are candidate genes. In acquired factors for COPD pathology, the adenoviral latent infection may enhance airway inflammation, leading to airflow obstruction. The current progress and future visions of genetic predisposition of COPD are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据