期刊
ATHEROSCLEROSIS
卷 190, 期 1, 页码 26-34出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.atherosclerosis.2006.02.021
关键词
genetics; calcium; atherosclerosis; EPHX2; smoking
资金
- NHLBI NIH HHS [N01-HC-48049, N01-HC-48050, N01-HC-48048, R01-HL69126, N01-HC-48047, N01-HC-95095] Funding Source: Medline
- NINDS NIH HHS [R01-NS41466] Funding Source: Medline
- DIVISION OF EPIDEMIOLOGY AND CLINICAL APPLICATIONS [N01HC095095, N01HC048049, N01HC048050, N01HC048048, N01HC048047] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL069126] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS041466] Funding Source: NIH RePORTER
Soluble epoxide hydrolase (EPHX2) catalyses the degradation of the vasoactive and anti-inflammatory epoxyeicosatrienoic acids and may play a role in the pathophysiology of atherosclerosis. 1337 African-Americans and 1645 Whites from the CARDIA study were genotyped for 22 and 15 EPHX2 single nucleotide polymorphisms (SNPs), respectively, to examine the associations of common EPHX2 haplotypes and genotypes with presence of coronary artery calcified plaque (CAC). The potential influence of cigarette smoking, which increases EPHX2 gene expression, on these associations was also assessed. In African-Americans, a common haplotype uniquely tagged by the R287Q polymorphism was associated with significantly greater risk for CAC (OR = 1.7; 95% CI = 1.04-3.0). In Whites, a common haplotype uniquely tagged by a polymorphism in Intron I I of the gene was associated with significantly greater risk for CAC (OR = 1.3; 95% CI = 1.02-1.6). These haplotype-tagging polymorphisms also showed significant associations with CAC in individual SNP analyses, and these relationships were significantly modified by smoking. This detailed investigation of the association of EPHX2 genetic variation with CAC supports EPHX2's emerging role as a risk factor for atherosclerosis, whose effects are influenced by smoking. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据