期刊
FOOD AND CHEMICAL TOXICOLOGY
卷 45, 期 9, 页码 1745-1751出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.fct.2007.03.008
关键词
risk assessment; patulin; probabilistic approach; second-order Monte Carlo simulation; organic; apple juice
The objective of the present study was to evaluate the patulin exposure of children consuming organic, handcrafted or conventional apple juice through a probabilistic approach and to evaluate the effectiveness of several risk management options aiming to reduce the risk for children due to patulin exposure. However, a large part of the data on patulin contamination of apple juice fell under the limit of detection (LOD). Different methods were tested to deal with these so-called left censored data and a uniform distribution with uncertain bounds was selected to handle this censorship. Variability and uncertainty assessment of patulin exposure showed that 0.9% [90% confidence interval (0): 0.3-1.8%] of the children consuming only organic apple juice exceed the tolerable daily intake (TDI). For consumers of conventional and handcrafted apple juice this was respectively 0.1% [90% Cl: 0-0.3%] and 0% [90% Cl: 0-0.2%]. Reduction of the patulin contamination in apple juice to concentrations below 25 mu g/kg reduced the percentage of the children exceeding the TDI to 0% [90%Cl: 0-0.2%] for organic apple juice. Reduction of the apple juice consumption was less effective than a reduction of the patulin concentration in apple juice and is only useful when the patulin concentration of apple juice is below 25 mu g/kg. (c) 2007 Elsevier Ltd. All rights reserved.
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