New gold(I) and silver(I) complexes of sulfamethoxazole: Synthesis, X-ray structural characterization and microbiological activities of triphenylphosphine(sulfamethoxazolato-N2)gold(I) and (sulfamethoxazolato)silver(I)

Sulfamethoxazole (SMTZ) reacts with Ph3PAuCl and AgCl in methanol/triethylamine to give [Ph3PAu(SMTZ(-1H+))] (SMTZ(-1H+) = sulfamethoxazolato anion) (1) and [Ag(SMTZ(-1H+))] (2). While the lattice of 1 contains single molecules with linear N-Au-P bonds, compound 2 comprises a two-dimensional polymeric assembly of the deprotonated SMTZ ligand and silver ions, which are coordinated by one oxygen and three nitrogens in a distorted tetrahedral array. The microbiologic activities (Mueller-Hinton broth dilution tests) of I and 2 were determined in relation to free sulfamethoxazole. (c) 2007 Elsevier B.V. All rights reserved.