期刊
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
卷 22, 期 5, 页码 555-568出版社
OXFORD UNIV PRESS
DOI: 10.1016/j.acn.2007.03.004
关键词
traumatic brain injury (TBI); diffusion tensor imaging (DTI); white matter; pediatric
资金
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000400, P41RR008079] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [P30NS057091] Funding Source: NIH RePORTER
- NCRR NIH HHS [P41 RR008079-13, M01 RR000400-407508, M01 RR000400-397968, P41 RR 008079, M01 RR000400-416998, M01 RR000400, P41 RR008079] Funding Source: Medline
- NINDS NIH HHS [P30 NS057091-02, P30 NS 057091, P30 NS057091, P30 NS057091-03, P30 NS057091-01, P30 NS057091-05, P30 NS057091-04] Funding Source: Medline
This study examined the sensitivity of diffusion tensor imaging (DTI) to microstructural white matter (W/M) damage in mild and moderate pediatric traumatic brain injury (TBI). Fourteen children with TBI and 14 controls ages 10-18 had DTI scans and neurocognitive evaluations at 6-12 months post-injury. Groups did not differ in intelligence, but children with TBI showed slower processing speed. working memory and executive deficits, and greater behavioral dysregulation. The TBI group had lower fractional anisotropy (FA) in three WM regions: inferior frontal, superior frontal, and supracallosal. There were no group differences in corpus callosum. FA in the frontal and supracallosal regions was correlated with executive functioning. Supracallosal FA was also correlated with motor speed. Behavior ratings showed correlations with supracallosal FA. Parent-reported executive deficits were inversely correlated with FA. Results suggest that DTI measures are sensitive to long-term WM changes and associated with cognitive functioning following pediatric TBI. (C) 2007 National Academy of Neuropsychology. Published by Elsevier Ltd. All rights reserved.
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