期刊
JOURNAL OF NEUROSCIENCE RESEARCH
卷 85, 期 8, 页码 1601-1605出版社
WILEY-LISS
DOI: 10.1002/jnr.21220
关键词
neurotrophins; p75NTR; Schwann cells; regulated intramembranous proteolysis; Nogo-66 receptor; axon regeneration
The neurotrophin receptor p75 (p75NTR) is expressed by both neurons and glia. Nerve injury triggers up-regulation of p75NTR in Schwann cells (SC) but not in central glia. In contrast to neuronal p75NTR, which mediates negative signals from myelin-associated proteins resulting in neurite collapse, glial p75NTR may play a positive role in nerve regeneration by forming neurotrophin chemoattractant gradients or by competitively antagonizing the NOGO/NgR/LINGO-1 signal through cell-cell contact or regulated intramembranous proteolysis (RIP) of p75NTR. This piece presents some recent evidence supporting this hypothesis. (c) 2007Wiley-Liss, Inc.
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