期刊
HAEMATOLOGICA
卷 92, 期 4, 页码 574-575出版社
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.10891
关键词
mantle cell lymphoma; MDM2 expression; survival; SNP309
类别
资金
- Interdisciplinary Center for Clinical Research (IZKF), University of Wurzburg
- European Grant [503351]
- Lymphoma Research Foundation (LRF), USA
- grant CICYT by the Spanish Ministry of Science [SAF 05/5855]
- Spanish Ministry of Education and Science (MEC)
We here show that increased expression of MDM2, a negative regulator of p53, correlates with inferior survival in a series of 43 mantle cell lymphomas. MDM2 overexpression is associated with copy number gains of the MDM2 locus in single tumors, but not with the recently reported MDM2 promoter SNP309.
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