期刊
DEVELOPMENTAL DYNAMICS
卷 236, 期 4, 页码 1055-1063出版社
WILEY
DOI: 10.1002/dvdy.21096
关键词
temperature-dependent sex determination; reptile; Sox9; Mis; Dmrt1; testis differentiation
Sex determination in vertebrates, the process of forming an ovary or testis from a bipotential gonad, can be initiated by genetic or environmental factors. Elements of the downstream molecular pathways underlying these different sex-determining mechanisms have been evolutionarily conserved. We find the first evidence that Sox9 expression is preferentially organized in the testis early in the temperature-sensitive period in a species with temperature-dependent sex determination (Trachemys scripta). This pattern occurs before sexually dimorphic Mis expression and in a temporal hierarchy that is similar to mammals. Furthermore, we extend previous findings that Dmrt1 expression at early stages of sex determination has a dimorphic pattern consistent with a possible upstream role in determining the fate of the bipotential gonad.
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