期刊
BRITISH JOURNAL OF NUTRITION
卷 97, 期 4, 页码 692-698出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0007114507666409
关键词
ellagic acid; cell adhesion molecule; NF kappa B; reactive oxygen species; atherosclerosis
Expression of cell adhesion molecules by endothelium and the attachment of monocytes to endothelium may play a major role in atherosclerosis. Ellagic acid (EA) is a phenolic compound found in fruits and nuts including raspberries, strawberries, grapes and walnuts. Previous studies have indicated that EA possesses antioxidant activity in vitro. In the present study, we investigated the effects of EA on the formation of intracellular reactive oxygen species, the translocation of NF kappa B and expression of vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 and endothelial leucocyte adhesion molecule (E-selectin) induced by IL-1 beta in human umbilical vein endothelial cells (HUVEC). We found that EA significantly reduced the binding of human monocytic cell line, U937, to IL-1 beta-treated HUVEC. The production of reactive oxygen species by IL-1 beta was dose-dependently suppressed by EA. Supplementation with increasing doses of EA up to 50 mu mol/l was most effective in inhibiting the expression of VCAM-1 and E-sclectin. Furthermore, the inhibition of IL-1 beta-induced adhesion molecule expression by EA was manifested by the suppression of nuclear translocation of p65 and p50. In conclusion, EA inhibits IL-1 beta-induced nuclear translocation of p65 and p50, thereby suppressing the expression of VCAM-1 and E-selectin, resulting in decreased monocyte adhesion. Thus, EA has anti-inflammatory properties and may play an important role in the prevention of atherosclerosis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据