期刊
DEVELOPMENTAL DYNAMICS
卷 236, 期 3, 页码 829-835出版社
WILEY-LISS
DOI: 10.1002/dvdy.21061
关键词
bhlh; transcription factor; immunostaining; expression pattern; neural development
资金
- NINDS NIH HHS [R01 NS37703] Funding Source: Medline
Accumulating evidence has suggested that the basic helix-loop-helix transcription factors play important roles in controlling neuronal fate specification and differentiation in the developing central nervous system. In this study, we report a detailed immunological study on the expression of Bhlhb5 in embryonic mouse spinal cord with a newly developed antibody. At the early stage of neural development, Bhlhb5 is specifically expressed in dI6 dorsal interneurons and in V1 and V2 ventral interneurons. At late stages of development, Bhlhb5 expression is detected in a subset of late-born dorsal association interneurons that migrate into the uppermost layer of the dorsal horn.
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