期刊
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 18, 期 1, 页码 235-243出版社
AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2006040394
关键词
-
资金
- NCRR NIH HHS [5 K12 RR023265-03, M01 RR001066, K12 RR023265, M01-RR01066] Funding Source: Medline
- NHLBI NIH HHS [K30 HL004136, HL004136] Funding Source: Medline
- NIDDK NIH HHS [DK007247, P01 DK002456, DK599445, N01 DK062204-007, T32 DK007247, DK02456] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [K12RR023265, M01RR001066] Funding Source: NIH RePORTER
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [K30HL004136] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P01DK002456, T32DK007247, N01DK062204] Funding Source: NIH RePORTER
Weight gain and central obesity are associated with insulin resistance, hypertension, and dyslipidemia in type 1 diabetes. These metabolic abnormalities are risk factors for kidney disease in the general population, but data addressing the relationship of central obesity with kidney disease in type I diabetes are limited. Whether waist circumference is associated with incident microalbuminuria and change in creatinine clearance was examined among 1279 participants who had type 1 diabetes and were enrolled in the Epidemiology of Diabetes Interventions and Complications Study, the observational extension of the Diabetes Control and Complications Trial (DCCT). Ninety-three of 1105 participants with normal albumin excretion rate (AER) at DCCT closeout developed incident microalbuminuria over 5.8 yr of follow-up. The hazard ratio for incident microalbuminuria that was associated with each 10-cm greater waist circumference at DCCT closeout was 1.34 (95% confidence interval 1.07 to 1.68), after adjustment for DCCT closeout age, gender, duration of diabetes, treatment group, smoking status, glycosylated hemoglobin, and AER. This increased risk was modestly attenuated when additional adjustment was made for levels of BP and serum lipids. Creatinine clearance declined by an average of 0.34 ml/min per 1.73 m(2) each yr over 8 yr of follow-up. Greater rate of decline in creatinine clearance was associated with greater age, conventional insulin therapy during the DCCT, smoking, and greater glycosylated hemoglobin and AER at DCCT closeout but not with waist circumference. In conclusion, waist circumference predicts the subsequent development of microalbuminuria in type 1 diabetes. In contrast, no association of waist circumference with decline in creatinine clearance was observed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据