期刊
SCHIZOPHRENIA RESEARCH
卷 89, 期 1-3, 页码 191-197出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.schres.2006.08.016
关键词
schizophrenia; working memory; fMRI; twin; genetic; inefficiency
类别
资金
- NIMH NIH HHS [MH52857, 1F31MH068111-01A2] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [F31MH068111, R01MH052857] Funding Source: NIH RePORTER
While behavioral research shows working memory impairments in schizophrenics and their relatives, functional neuroimaging studies of patients and healthy controls show conflicting findings of hypo- and hyperactivation, possibly indicating different relationships between physiological activity and performance. In a between-subjects regression analysis of fMRI activation and performance, low performance was associated with relatively lower activation in patients than controls, while higher performance was associated with higher activation in patients than controls in DLPFC and parietal cortex, but not occipital cortex, with unaffected twins of schizophrenics being intermediate between the groups. Accordingly, this supports the idea that both hyper and hypoactivation may be possible along a continuum of behavioral performance in a way consistent with a neural inefficiency model. Further, this study offers preliminary evidence that the relationship between behavior and physiology in schizophrenia may be heritable. (c) 2006 Elsevier B.V. All rights reserved.
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