期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 64, 期 17, 页码 2306-2322出版社
BIRKHAUSER VERLAG AG
DOI: 10.1007/s00018-007-7121-z
关键词
RecQ helicases; DNA repair; homologous recombination; chromosomal instability; cancer pre-disposition; premature aging; telomeres
The RecQ helicases belong to the Superfamily II group of DNA helicases, and are defined by amino acid motifs that show sequence similarity to the catalytic domain of Escherichia coli RecQ. RecQ helicases have crucial roles in the maintenance of genome stability. In humans, there are five RecQ helicases and deficiencies in three of them cause genetic disorders characterised by cancer predisposition, premature aging and/or developmental abnormalities. RecQ helicase-deficient cells exhibit aberrant genetic recombination and/or DNA replication, which result in chromosomal instability and a decreased potential for proliferation. Here, we review the current knowledge of the molecular genetics of RecQ helicases, focusing on the human RecQ helicase disorders and mouse models of these conditions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据