期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 64, 期 18, 页码 2329-2333出版社
BIRKHAUSER VERLAG AG
DOI: 10.1007/s00018-007-7135-6
关键词
hyperthermia; apoptosis; caspases; Hsp70; c-Jun N-terminal kinases
资金
- NCI NIH HHS [5T32 CA09480] Funding Source: Medline
- NIEHS NIH HHS [P30 ES07784] Funding Source: Medline
- NATIONAL CANCER INSTITUTE [T32CA009480] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [P30ES007784] Funding Source: NIH RePORTER
Hippocrates' assertion that what the lance does not heal, fire will' underscores the fact that for thousands of years heat has been used to treat a variety of diseases, including cancer. Indeed, spontaneous tumor remission has been observed in patients following feverish infection [1], and expression of activated oncogenes, such as Ras, can render tumor cells sensitive to heat compared with normal cells [2, 3]. In the past, a primary drawback to the use of heat as a clinical therapy was the inability to selectively focus heat to tumors in situ. Of late, however, several approaches have been devised to deliver heat more precisely, including the use of heated nanoparticles, making hyperthermia a more clinically tractable treatment option [4, 5]. Despite these practical advances, the mechanisms responsible for heat shock-induced cell death remain controversial and ill-defined. In this Visions and Reflections we discuss recent findings surrounding the initiation of heat shock-induced apoptosis, and propose future areas of research.
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