期刊
CARBOHYDRATE POLYMERS
卷 69, 期 2, 页码 272-279出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2006.10.024
关键词
polyguluronate sulfate; alginate; anticoagulant activity; anti-inflammatory activity
Low-molecular-weight polyguluronate sulfate (LPGS) was prepared as a heparinoid by chemical sulfation of polyguluronic acid (PG), which was isolated from the hydrolysate of alginate by pl-l-fractionated precipitation. The structure of LPGS was elucidated based on FT-IR and 2D NMR spectroscopy. Sulfation was demonstrated to occur at the C-2 and C-3 positions of the guluronic acid residues and the degree of substitution (DS) was 1.53 per monosaccharide residue. The weight-averaged molecular weight of LPGS was 11.4 kDa determined by high performance gel permeation chromatography (HPGPC). The in vitro anticoagulant activity and in vivo anti-inflammatory activity of LPGS were evaluated. Results showed that LPGS significantly prolonged the whole blood clotting time and activated partial thrombinplastin time (APTT), and exhibited considerable anti-inflammatory activity in cotton pelletinduced granuloma in rats. (C) 2006 Elsevier Ltd. All rights reserved.
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