期刊
MAGNETIC RESONANCE IN MEDICINE
卷 57, 期 4, 页码 704-713出版社
WILEY
DOI: 10.1002/mrm.21179
关键词
phMRI; cluster analysis; functional connectivity; amphetamine; rat
We investigated the functional connectivity structure underlying the widespread relative cerebral blood volume (rCBV) response to d-amphetamine in the rat brain by systematically analyzing the intersubject correlations between the response amplitudes in 48 atlas-defined brain structures. A cluster analysis resolved three distinct networks of brain regions that exhibited closely coupled responses: one corresponding to primary dopamine projections from the midbrain to the striatum, a second consisting predominantly of forebrain cortical and basal ganglia regions that share a widespread correlation pattern resembling the univariate group response, and a third including structures in the periventricular dopamine system. These results suggest that different functional networks underlie the brain's response to d-amphetamine. This approach may provide important new insights regarding the central systems that underlie pharmacological action.
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