期刊
CELLULAR AND MOLECULAR LIFE SCIENCES
卷 64, 期 7-8, 页码 906-921出版社
SPRINGER BASEL AG
DOI: 10.1007/s00018-007-6481-8
关键词
telomerase; telomere; reverse transcriptase; cancer therapy
Telomeres are protective structures located at the ends of all eukaryotic chromosomes. Telomere shortening upon cell division restricts the proliferative capacity of most normal human cells due to the lack of telomerase, an enzyme synthesizing telomeric DNA de novo. Since most tumor cells are reliant on the activity of telomerase to maintain the stability of predominantly short individual telomeres, inhibition of this enzyme presents an attractive approach for a mechanism-based anticancer therapy. Here, we review advances and obstacles in targeting telomerase and telomeres and discuss potential applications of such approaches for the clinic.
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