期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 184, 期 1-2, 页码 17-26出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2006.11.026
关键词
MS; EAE; neuronal damage; HMG-CoA reductase; EGCG; TRAIL
Multiple sclerosis (MS) is the most common chronic demyelinating disease of the central nervous system (CNS) and the major cause of neurological disability in young adults in Western countries. In spite of intensive research efforts, treatment options established to date do not sufficiently prevent the accumulation of tissue damage and clinical disability in patients with MS. We here describe recently identified molecules responsible for the inflammatory and the neurodegenerative processes in MS and its animal model, experimental autoimmune encephalomyelitis (EAE), and review new treatment options targeting both aspects of this disease. (c) 2006 Elsevier B.V. All rights reserved.
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