期刊
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 26, 期 8-9, 页码 1145-1149出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770701526978
关键词
thrombin binding aptamer; inversion of polarity site
Several researches have been devoted to structure-activity relationship and to post-SELEX modifications of the thrombin binding aplamer (TBA), one of the first aplamers discovered by the SELEX methodology. However, no studies on TBA dealing with the effects of introduction of inversion of polarity sites have been reported yet. In this frame, we have undertaken the synthesis and the study of a mini-library composed of several TBA analogues containing a 3'-3' or a 5'-5' inversion of polarity site at different positions into the sequence. Particularly, in this article, we present preliminary results about their structural and biological properties.
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