期刊
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 26, 期 8-9, 页码 1087-1093出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770701516268
关键词
oligoribo- and deoxyribonucleotides; stereospecific phosphotriester synthesis; phosphorothioate analogues
An approach to the solid phase synthesis of natural and modified oligonucleotides using phosphotriester technique has been developed. Particularly, this method allows the synthesis of ribo- and deoxyribo-oligonucleotides containing various 2'-modified mononucleotides as well as stereodefined nucleotide phosphorothioate analogues.
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