期刊
CANADIAN JOURNAL OF ZOOLOGY
卷 90, 期 4, 页码 507-520出版社
CANADIAN SCIENCE PUBLISHING
DOI: 10.1139/Z2012-013
关键词
neuropeptide; hormone; G-protein-coupled receptor; guanylate cyclase; malpighian tubule
类别
资金
- USDA-NRI-CSREES [2007-35604-17759]
Diuresis, the removal of excess metabolic waste through production of primary urine while maintaining homeostasis, is an important biological process that is tightly regulated by endocrine factors. Several hormonal components that act as diuretic or antidiuretic factors in insects have been identified in the last few decades. Physiological mechanisms responsible for ion and water transport across biological membranes have been intensively studied. The large amount of data rapidly accumulating in the genomics era has led to an increased dependence on reverse genetic and physiological approaches, first identifying candidate genes and subsequently deriving functions. In many cases, the reverse approaches have been highly successful, especially in studies of the receptors for diuretic factors, which are mainly G-protein-coupled receptors. This review summarizes research on insect diuretic and antidiuretic endocrine factors, and their receptors. Emphases of the review are given to the genomics of ligands and their receptors, as well as to their implications for evolution and function.
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