期刊
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
卷 26, 期 6-7, 页码 861-864出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/15257770701504025
关键词
pronucleotides; cycloSal; anti-HIV; enzymatic activation; antiviral activity
A new class of lock-in modified cyclo Sal-pronucleotides has been synthesized. On the example of 5-diacetoxymethyl-cycloSal-d4T-monophosphate (5-di-AM-cycloSal-d4TMP), the concept of enzymatically activated cycloSal-pronucleotides is elucidated. Synthesis, hydrolysis studies, and antiviral activities against HIV are presented.
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