期刊
NEUROPSYCHOLOGIA
卷 45, 期 5, 页码 1065-1079出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropsychologia.2006.09.009
关键词
semantic memory; aphasia; semantic dementia; access impairment; refractory
资金
- MRC [G0501632] Funding Source: UKRI
- Medical Research Council [G0501632] Funding Source: Medline
- NIMH NIH HHS [MH64445] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [P50MH064445] Funding Source: NIH RePORTER
This study examined the full range of effects associated with semantic access impairment - namely, refractory variables (semantic relatedness, speed of presentation and item repetition), inconsistency, the absence of frequency effects and facilitation by cues - in a series of stroke patients with multimodal semantically impairment. By investigating all of these factors in a group of patients who were not specifically selected to show access effects, we were able to establish (1) whether this pattern is a common consequence of infarcts that produce semantic impairment and (2) if these symptoms co-occur. All of the patients showed effects of cueing and an absence of frequency effects in comprehension. Patients whose brain damage included the left inferior prefrontal cortex (LIPC) also showed marked effects of refractory variables; in contrast, two patients with temporal-parietal but not frontal lesions were less sensitive to these variables. Parallel results were obtained for cyclical naming and word-picture matching tasks suggesting that the LIPC plays a role in semantic selection as well as lexical retrieval. Rapid presentation and item repetition is likely to have increased the selection demands in both of these tasks in a similar fashion. Unlike patients with classical semantic access impairment, our semantically impaired stroke patients showed significant test-retest consistency, indicating that their difficulties did not result from an unpredictable failure of semantic access-instead, their deficits were interpreted as arising from failures of semantic control. (c) 2006 Elsevier Ltd. All rights reserved.
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