期刊
FRONTIERS IN BIOSCIENCE-LANDMARK
卷 12, 期 -, 页码 1544-1551出版社
FRONTIERS IN BIOSCIENCE INC
DOI: 10.2741/2167
关键词
Friend retrovirus; cytotoxic T cells regulatory; vaccination; response; chronic; infection; review
资金
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [Z01AI000753, ZIAAI000753] Funding Source: NIH RePORTER
T cells are critical to control acute infection of a host with retroviruses but they are usually unable to prevent the development of chronic infections. This review summarizes studies from the Friend virus mouse model that reveal some of the mechanisms by which T cells control chronic retroviral infection, and also reveal why these responses ultimately fail to fully eradicate infection. Also summarized are findings from vaccine studies demonstrating the immunological requirements for the prevention of chronic retroviral infection. The implications of these findings for chronic infections in humans are discussed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据