期刊
CURRENT PHARMACEUTICAL DESIGN
卷 13, 期 25, 页码 2621-2637出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/138161207781663000
关键词
5-Hydroxytryptamine; serotonin; central nervous system (CNS); anti-migraine drugs; G-proteins; 5-HT receptor family
Serotonin (5-HT) receptors are part of the G protein-coupled and ligand-gated ion channel families. 5-HT exerts its diverse actions by binding to cell surface receptors which can be classified into seven distinct families (5-HT, to 5-HT gamma) according to their structural diversity and mode of action. Some of the 5-HT families are comprised of multiple receptors which share similar structural and mechanistic properties but display very different operational profiles. Evidence continues to mount in support of the important roles of the 5-HT receptors in various neuropsychiatric disorders such as anxiety, depression, schizophrenia, migraine and drug addiction. The 5-HT receptors may also play an important role in obesity, aggression, sexual behaviour and cardiovascular disorders. A number of selective/non-selective 5-HT agonist and antagonist ligands (drugs) have been developed to challenge many of these disease states.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据