期刊
GENOME BIOLOGY
卷 8, 期 5, 页码 -出版社
BIOMED CENTRAL LTD
DOI: 10.1186/gb-2007-8-5-r82
关键词
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资金
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG002341] Funding Source: NIH RePORTER
- NHGRI NIH HHS [R01HG002341, R01 HG002341] Funding Source: Medline
We develop a strategy for estimating gene expression on Affymetrix Exon arrays. The method includes a probe-specific background correction and a probe selection strategy in which a subset of probes with highly correlated intensities across multiple samples are chosen to summarize gene expression. Our results demonstrate that the proposed background model offers improvements over the default Affymetrix background correction and that Exon arrays may provide more accurate measurements of gene expression than traditional 3' arrays.
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